Chronic diseases like diabetes and hypertension are increasingly prevalent worldwide, posing significant challenges to healthcare systems and impacting patients’ quality of life. By 2019, diabetes affected 463 million people globally, a number projected to rise substantially by 2045 (Saeedi et al., 2019). Similarly, 1.13 billion people were estimated to have hypertension, with expectations of further increases by 2025 (Bello-Ovosi et al., 2018). Managing these conditions necessitates a comprehensive approach, including medication, lifestyle changes, and self-management education, which can adversely affect patients’ quality of life. Health-related quality of life (HRQOL) encompasses physical, psychological, and social well-being, and is crucial in understanding the broader impacts of chronic diseases. Despite extensive research in high-income countries, there is limited data on HRQOL among Nigerian patients with diabetes and hypertension. This study aims to examine HRQOL in these patients at the National Assembly Clinic, Abuja, assessing factors like health literacy and co-morbidities. Findings will inform healthcare providers and policymakers, advocating for more holistic, patient-centered care. Understanding HRQOL in this context will improve management strategies, enhance patient outcomes, and contribute to the development of supportive policies for individuals with diabetes and hypertension.