This research explores the intricate relationship between globalization, Nigeria’s political economy, and its foreign policy, focusing on the period from 1999 to 2009. Globalization, marked by heightened international exchange of goods, services, and capital, has significantly influenced Nigeria’s interactions with the global community. The study investigates the historical evolution of Nigeria’s foreign policy, examining its determinants and the impact of globalization on its development. Through an in-depth analysis of Nigeria’s diplomatic relations with key global actors such as the United States, European Union, China, India, and other African states, the research evaluates how globalization has shaped Nigeria’s foreign policy landscape during the specified period. By addressing these aspects comprehensively, the study aims to contribute to a nuanced understanding of the complex interplay between globalization dynamics and Nigeria’s foreign policy formulation and execution.