Nurses are sometimes frustrated by regulations or policies directing nursing practice, especially when they are generated by those with little knowledge of healthcare. This study examined “the knowledge and perception of Politics and policy making among Nursing students in the College of Nursing and Midwifery Jos Plateau State” and it also examined the factors influencing Nursing students’ involvement in politics and policy making. Descriptive survey research design was adopted for this study. Data were collected using questionnaire method of data collection. Ballot method of simple random sampling technique was adopted for this study. Face and content validity of the instrument was carried out by the project supervisor. Data generated was presented and analyzed using frequency and percentage. In summary, review of the literature revealed that there are interrelated and complex factors that influenced and contributed to limited Nursing students participation in health policy development. Nurses face challenges in being involved in health policy development at the grassroots level, as well as at the government level. Nursing students and Nurses believe that they are excluded and are not part of the health policy development process and that they are not present in large enough numbers to make a difference. Other major factors acting as barriers to participation include inadequate political and policy development skills, lack of status of women that are also shapers of the image of nursing profession, lack of education and lack of supportive organizational structures. However, research studies revealed that when Nurses are involved and successfully influence health policy development; there are benefits to health care delivery. There are factors which could facilitate nurses’ participation, in this regard include: effective leadership, political savvy, education, knowledge and understanding the health policy development process. In conclusion, majority of the Nursing Students in the College of Nursing and Midwifery Jos, Plateau State have adequate knowledge on politics and policy making and have what it takes to be involved in politics and policy making as revealed in table 4.2 but are not ready to be politically involved due to the factors influencing their involvement in politics and policy making as revealed in table 4.4 which 65.6% of the respondents said it is time consuming, 16.2% of the respondents said it is not important for professional growth, 51.3% of the respondents said gender and 65.6% of the respondents said it is dangerous to be politically involved and also due to their perception about politics and policy making as revealed in table 4.3 which 59.7% of the respondent don’t have an individual passion for politics and policy making and 10.4% of the respondents said politics and policy making is for some selected group of profession. Nurses should be encouraged to be politically involved and to play active roles so that their potentials can be nurtured toward becoming a voice in the decision making and so that the benefit of politics and policy making can be enjoyed by nursing profession and Nurses.